<!--[if gte mso 9]><xml> <o:OfficeDocumentSettings> <o:AllowPNG /> </o:OfficeDocumentSettings> </xml><![endif]--> <p class="MsoNormal">Avusturalyalı ve Amerikalı bilim insanları farelerde kas yaşlanmasının etkilerini geri çevirebilecek bir bileşik geliştirdiler ve bunun, insan yaşlanmasını geri çevirmek konusundaki anahtarlardan biri olduğunu söylediler.</p> <p class="MsoNormal">Deneylerde, bu bileşik farelere daha fazla enerji verdi, iltihapları azalttı ve insülin direncine karşı ciddi gelişmeler sağladı. Bilim insanları bunun, yaşlanmayı sadece yavaşlatmadığını, aynı zamanda geriye çevirdiğini söylediler. Bir diğer deyişle bu değişimin, 60 yaşındaki bir bireyin 20 yaşında hissetmesi gibi olduğunu aktardılar. Üstelik, insan üzerindeki denemelerin sadece 1 yıl içerisinde başlayabileceğini belirttiler. Araştırma sonuçları 19 Aralık 2013'te <span style="mso-bidi-font-style: italic">Cell</span> dergisinde yayımlandı. New South Wales Üniversitesi'nde görev alan ve Harvard Tıp Okulu'nda arka planı bulunan genetik bilimci Prof. Dr. David Sinclair şunları söylüyor:</p> <p class="MsoNormal"><span style="mso-bidi-font-style:italic">"20 yıldır moleküler düzeyde yaşlanma üzerine çalışmaktayım ve yaşlanmanın tersine çevrilebileceğini göreceğim bir günü yaşayabileceğimi hiç sanmıyordum. Biraz bile yavaşlatabilsek kendimizi şanslı sayarız diye düşünüyordum. [Deneydeki] fareler, daha fazla enerjiye sahip oldular, kasları sanki egzersiz yapmış gibi güçlendi ve diyet-egzersiz ikilisinin etkilerini sadece 1 hafta içerisinde elde ettik. Bunun, insanların daha uzun süreler sağlıklı kalmasını sağlayacağını ve yaşlanmadan kaynaklı hastalıklara yakalanmalarını önleyeceğini düşünüyoruz."</span></p> <p class="MsoNormal">Araştırmacılar, yaşlı farelerdeki belli başlı hastalıkları da incelediler. Prof. Sinclair devam ediyor:</p> <p class="MsoNormal"><span style="mso-bidi-font-style:italic">"Diyabete, kas zayıflığına veya zaafiyetine, artirit gibi hastalıklara neden olan iltihaplanmalara da baktık. Yaşlanmanın tüm bu olumsuz etkileri tersine dönmüştü ve bu, oldukça çarpıcı bir sonuç."</span></p> <p class="MsoNormal">Ekiplerinin, kas da dahil olmak üzere tüm kaslarda bulunan ve yaşlanmaya neden olan yeni bir sebebi keşfetiklerini belirtiyor ve şunları söylüyor:</p> <p class="MsoNormal"><span style="mso-bidi-font-style:italic">"Düşündüğümüz şu: vücudumuzda iki set kromozom bulunuyor. Kromozomların bildiğimiz kısımlarına genom diyoruz ama bir de üzerinde çok düşünmediğimiz diğer DNA'larımız var: annelerimizden aldığımız mitokondriyal DNA'larımız. Bulgularımıza göre, yaşlanma süresince bu iki genom veya kromozom, birbiriyle pek konuşmuyor. Bu tıpkı, evli çiftlerin ilk evlendiklerinde birbirleriyle konuşmaları ama aradan 20 yıl geçince, en azından bazı vakalarda, bu iletişimin sona ermesi gibi. Bundan yola çıkarak, biz yaşlandıkça giderek azalan bir kimyasal keşfettik. Kısa adı NAD olan bu kimyasalın uzun ismi Nikotinamid adenin dinükleotit. Biz gençken NAD seviyelerimiz oldukça yüksektir. Eğer egzersiz ve diyet uygularsak, bu seviye yüksek kalır. Ama tıpkı deneyimizdeki fareler gibi, bizler de yaşlandıkça, bu kimyasalın seviyesi %50 civarında azalır. İşte bu yüzden, geliştirdiğimiz ilacı vererek bu kimyasalın düzeyini arttırabiliriz."</span></p> <p class="MsoNormal">Araştırmanın ikinci aşaması insan denekleri içeriyor ve muhtemelen önümüzdeki sene başlayacak. Prof. Sinclair bu kimyasalın kolayca erişilebilir hale ne zaman geleceğini tahmin etmek istemiyor; ancak bu süreci hızlandıracak bir firma kurduğunu belirtiyor. Son olarak şunları aktarıyor:</p> <p class="MsoNormal"><span style="mso-bidi-font-style:italic">"Eğer ki insanlarda denemeyi başarabilirsek, bu araştırmalar milyonlarca dolar tutacak ve bunları yapabilmemiz için, paraya ihtiyacımız var. Mekanizma bu."</span></p> <p class="MsoNormal">Çeviren: <b>ÇMB (Evrim Ağacı) </b>Kaynak: <a href="http://www.abc.net.au/news/2013-12-20/scientists-develop-anti-ageing-process-in-mice/5168580">ABC</a></p> <p class="MsoNormal"><a href="http://evrimagaci.org/fotograf/64/5264" target="_blank"><strong>http://evrimagaci.org/fotograf/64/5264</strong></a></p> <!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:TrackMoves /> <w:TrackFormatting /> <w:HyphenationZone>21</w:HyphenationZone> <w:PunctuationKerning /> <w:ValidateAgainstSchemas /> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:DoNotPromoteQF /> <w:LidThemeOther>TR</w:LidThemeOther> <w:LidThemeAsian>X-NONE</w:LidThemeAsian> <w:LidThemeComplexScript>X-NONE</w:LidThemeComplexScript> <w:Compatibility> <w:BreakWrappedTables /> <w:SnapToGridInCell /> <w:WrapTextWithPunct /> 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